This second form of skin cancer arises in the surface cells, the squamous epithelium which is the outer or finished layer of our skin. The cause of squamous cell cancer is the same as basal cell: solar and environmental radiation. Additionally, squamous cell cancer may arise in a chronic burn or wound scar and is then called Marjolin's Ulcer. Solar or X-radiation causes gradual mutation of dividing cells which first deviate from normal but then evolve completely into cancer. The effect and appearance of squamous cell cancer is far more malevolent. Once developed to sufficient size this cancer may spread to other parts of our bodies by lymphatic and blood vessel dissemination. This process of metastasis further complicates the otherwise similar action of local tissue destruction as occurs with basal cells. A distant metastasis will grow invasively and destroy the organ to which it has spread. Squamous cell cancers grow more rapidly, are uglier and larger than their counterpart basal cell tumors and require a more extensive margin of removal.
Earliest squamous cancer appears as a non-invasive (non-metastasizing) superficial form, which arises within preceding actinic keratosis. This form is called "Bowen's Disease"; for the pathologist who recognized it. It may be treated more conservatively with a narrower margin of excision or even with Efudex as used for actinic keratoses. The problem again is recognition. The greatest number of these is surgically excised with good outcomes as our treatment course is based on worse case expectation.
Larger squamous cell cancers take much the same physical forms as basal cell, only in each case more pronounced. They may form as tumorous masses or thick crusty growths but in both forms seem to outgrow their blood supply, rapidly progressing to unsightly ulceration. Early squamous cell cancer may mimic the nodular-ulcerative form of basal cell cancer. The distinction in diagnosis is important, as surgical excision of squamous cell cancer requires a wider margin of clear tissue removal. Patients with large advanced squamous cell cancer must be surveyed for distant spread of their disease. If found, such metastases require treatment as well. The necessity for wider margins of excision in squamous cancer often leads to the need for skin grafts or local tissue flap transfers to close larger wound defects. Such procedures test the plastic surgeon's skill to its highest degree.
Clinical Examples of Grafts/Flaps/Adjacent Tissue Transfers